Custom Peptide Synthesis

Superior Processes

Peptides International has earned the reputation of providing exceptionally high quality custom peptide synthesis products to the research community. We specialize in the custom synthesis of 100 mg quantities or greater with purity levels of 95% or greater. Amino acid analysis ratios, actual mass spectral data, and analytical HPLC chromatograms are provided with custom peptides. Catalog peptides include analytical HPLC chromatograms. Please inquire for further details. If you require confidentiality for your custom project, please contact our custom services specialists for additional assistance.

Multi-Disulfide Peptides

Interested in mini-proteins with multiple disulfide bonds? PI researchers have extensive experience folding these highly complicated molecules to their biologically active forms. Examples include native molecules and analogs of conotoxins, defensins, hepcidins, chemokines, ion channel blockers (ShK, HwTX4, charybdotoxin, iberiotoxin, margatoxin, ProTx-II, mu-conotoxins, etc). They can also customize with labels such as TAMRA, FITC or Biotin using a mini-PEG™ spacer.

Peptide-Protein Conjugates

Peptide-protein conjugates have a variety of applications, including the stimulation of antibodies for immunization. These conjugates can be customized as needed, including combinations with proteins such as Albumin, Ovalbumin, and Ferritin. Selective heterobifunctional crosslinkers allow for selective attachment of a Cys-containing peptide to the protein of your choice. Using KLH-MCC will help streamline this reaction, and the product (KLH-6000-PI) is conveniently kept in stock at all times.

Peptide Derivatives

Fluorescence resonance energy transfer (FRET) occurs when excitation energy is transferred from an excited fluorescent donor to a quenching acceptor in a distance-dependent manner. Cleavage of a scissile peptide bond within a fluorescence quenched substrate leads to separation of the intramolecular donor-acceptor pair, thus allowing an increase in fluorescence. The fluorescence increase is proportional to the amount of peptide hydrolyzed. If you need to design a substrate for a newly discovered enzyme or application, contact our specialists to begin your Substrates by Design™ project today.

Post Translation Modification

Including: Glycosylation, Phosphorylation, Fatty Acylation, Pegylation, Cyclization, and Disulfide Bonds

Peptide Synthesis

Including: Classical/Solution, Solid-Phase, Native Chemical Ligation, and Dendrimeric RGD Platforms

Peptidomimetics

Including: Hydroxyethylene Isostere, Reduced Peptide Bonds, Aldehydes, Chloromethylketones, Depsipeptides, and phosphonates

Multi-step Organic Synthesis

Including: Novel Amino Acid Derivatives, Stereo Selective Synthesis, Special Protecting Groups, Natural Product Synthesis, and Chromogenic / Fluorogenic Substrates

Pricing?

The price of a synthesis is dependent on the complexity of the product. Even short peptides can represent difficult synthetic challenges (e.g., those that contain several tryptophans or histidines, or oxidation-prone residues, such as methionine, cysteine, or tryptophan, or sequences with long stretches of alanines or other aggregation-prone residues). For this reason, each sequence must be quoted individually, and for equivalent purity you will find Peptides International's pricing very competitive.

Here's how...

Just click on the Quote Request  menu at left to fill out a Custom Quotation.

If you wish to speak to a technical specialist please call 800-777-4779 or 502-266-8787.   Business hours are 8:30 - 6:00 ET (New York time). If you would like to fax your quotation, please print the pdf form and fax it to 502-267-1329. If you need additional information please feel free to send your question via email to peptides@pepnet.com . We look forward to hearing from you and hope that Peptides International may be of service to your research needs.