Custom Peptide Synthesis and Chemistry Services

At Peptides International, we specialize in meeting our customer's needs and delivering the highest purity in the industry. Hallmarks of our custom services include:

Peptides: simple to complex
Libraries: soluble and resin-bound
Bulk Resins and Amino Acids
Substrates by Design™

Peptides International, established in 1983, is your premier choice for specialized custom synthesis services in the area of specialty organic molecules, peptides, cysteine-rich peptides such as toxins and chemokines, peptidomimetics, and peptide-organic conjugates to pharma, biotech, and academic researchers worldwide.

The PI laboratories, updated and expanded in 2007, consist of well-equipped R&D labs, a pilot plant with 100-liter reactor system, in-process control instrumentation, purification systems and high-capacity freeze dryers. Incoming raw materials, as well as finished goods, are analyzed using state-of-the-art methods including HPLC, MS, AAA, UV and FTIR spectroscopy, polarimetry, and traditional organic analytical techniques. With these capabilities and the experience of its staff, Peptides International is able to offer effiecient and cost effective solutions to serve the challenging needs of modern peptide-based drug discovery and development.

Our team of scientists consists of experts in the areas of organic synthesis, peptide synthesis (solution and solid phase chemistry), protein chemistry, polymer science, and chromatographic separations. We also have extensive experience in the area of Cysteine-rich peptides and folding these molecules to their biologically active form. We also excel in all types of peptide modifications such as phosphorylation, depsi-peptide bond formation, HET isostere incorporation, fatty acylation, fluorescent derivatization, and isotopic derivatization. This experience base enables us to offer efficient and cost effective solutions to serve the challenging needs of modern peptide-based drug discovery and development.

Put our chemists to work for you and experience the success that your program deserves.
The Peptides International Difference...

Experienced and dedicated team with expertise in Peptide Science
Organic chemistry
Glycochemistry
Pegylation, phospho-peptides
CLICK chemistry derivatization
Peptide-chelate conjugates
Cysteine-rich peptides (toxins, chemokines, hepcidins, defensins)
Fluorescently labeled peptides (including FRET substrates)
pNA and AMC C-terminal custom peptide substrates
Complex structures (post-translational modifications)
Peptide bond mimietics (depsi, HET, reduced)
Cold isotope labeled mass spec and NMR reference peptides
Selective protein-peptide conjugation service (KLH or BSA)
Scale up and technology transfer
Randomized peptide libraries
Stapled peptides (stabilized alpha helical peptides)

High quality building blocks
Natural and unusual amino acid derivatives
Reagents for CLICK chemistry
Glycosylated amino acids
CLEAR-OX™

US based modern facility
Hi-Thru-Put lab equipped with ABI, Prelude and Symphony synthesizers
Automatic Pioneer, Sonata, and CSBio synthesizers to 50 gram scale
Microwave synthesizer
Prep-HPLC equipment from small scale to Biotage KP-250
Lyophilization and vialing capabilities and bulk up to kilo scale
Pilot plant with 100L reactor systems

Analytical services
Amino acid analysis / peptide content
ES-MS, analytical HPLC
Optical rotation, UV

Expert technical support & dedicated customer service
Decades of experience
Customer-centric focus and service

Strict confidentiality, molecular design consultations, project management, technology transfer