Encephalitogenic Determinants and EAE Related
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Autoimmune Disease: Multiple Sclerosis (MS) Type IV T-cell mediatedAutoantigen: myelin basic protein, myelin proteolipid protein Consequence: Brain degeneration and paralysis | ||
| Experimental Autoimmune
Encephalomyelitis (EAE, aka Experimental Allergic Encephalomyelitis) in rodents is
the animal model of demyelinating diseases such as multiple sclerosis (1). It is believed
that demyelination plaques that are randomly scattered throughout white matter in the
central nervous system (CNS) are responsible for disease symptoms. Myelin basic protein
(MBP) and Myelin Proteolipid Protein (PLP) have been used to induce EAE. MBP is highly
immunogenic upon its administration with induction being noted by the signature secretion
of both IFN-g and TNF-a. Fragments of MBP, Acetyl-MBP (1-11) from
rat [PMB-3658-PI] (2) and mouse [PMB-3657-PI] (3) are reported
to be the minimally active fragments and useful for EAE induction. Recent reviews of interest address the need for use of human stem-cell models to elucidate causes of neuronal dysfunction in parallel with current transgenic animal models due to the limitations of relying solely on the EAE models (4, 5). It is hoped that researchers will be successful at devising therapeutic routes and cures for the millions of people that suffer from MS and other demyelinating diseases.
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MOG (35-55) and PLP (139-151) Available:
MOG (35-55) is a highly studied fragment to determine the immunologic basis of the high encephalitogenicity of myelin/oligodendrocyte glycoprotein (MOG), a minor component of myelin in the CNS that is widely used to induce EAE. Peptides International is pleased to offer this immunodominant, T cell epitope, MOG (35-55), in addition to our other EAE-related peptides. Additionally available products include myelin PLP (139-151) and also OVA (257-264) and OVA Peptide (323-339), which are both immunodominant epitopes of ovalbumin (6). Please call us today to place an order or to contact our technical specialists if your research requires related antigenic fragments.
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| 1. P.E.
Bigazzi, Clin. Immunol. Immunopathol. 77, 3 (1995). 2. J.E. Fenyk-Melody, A.E. Garrison, S.R. Brunnert, J.R. Weidner, F. Shen, B.A, Shelton, and J.S. Mudgett, J. Immunol., 160, 2940 (1998). 3. S.D. Wolf, B.N. Dittel, F. Hardardottir, and C.A. Janeway, J. Exp. Med., 184, 2271 (1996). 4. J. Imitola, E.Y. Snyder, and S.J. Khoury, Physiol. Genomics 14, 171 (2003). 5. R.J. Jakel , B.L. Schneider, and C.N. Svendsen, Nature Reviews Genetics 5, 136 (2004). 6. F.R. Carbone, S.J. Sherry, J. Butler, S. Rodda, and M.W. Moore, Int. Immunol. 4, 861 (1992). |
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CODE |
AUTOIMMUNE AGENTS |
VIAL |
USD |
| PMG-3660-PI |
MOG (Rat, Mouse, 35-55) Myelin Oligodendrocyte Protein (35-55) H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser- Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH Encephalitogenic Determinant |
1 mg |
125 |
PMB-3657-PI |
Acetyl-Myelin Basic Protein
(Mouse, 1-11) Ac-MBP (1-11) Ac-Ala-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-OH Encephalitogenic Determinant |
1 mg |
95 375 |
PMB-3658-PI |
Acetyl-Myelin Basic Protein
(Human, Rat, 1-11) Ac-MBP (Human, Porcine, Rat 1-11) Ac-Ala-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-His-Gly-OH Encephalitogenic Determinant |
1 mg |
95 375 |
PLP-3602-PI |
Myelin PLP (139-151) PLP 139 -151 Myelin Proteolipid Protein (139-151) H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro- Asp-Lys-Phe-OH HSLGKWLGHP Encephalitogenic Determinant |
1 mg |
75 295 |
POV-3636-PI |
OVA Peptide (323-339) Chicken ovalbumin fragment (323-339) H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala- Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH T-cell Activating Peptide |
1 mg |
95 375 |
POV-3659-PI |
OVA Peptide (257-264) Chicken ovalbumin fragment (257-264) H-Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu-OH T-cell Activating Peptide |
1 mg |
50 195 |
Larger quantities available, please inquire. |
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Please contact Peptides International for ordering
information. |
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