FMOC-Amino Acid PHYSICAL PROPERTIES

Common Fmoc Amino Acids, Molecular Weight, Side Chain
Protecting Group, and TLC Information

peptides
Fmoc-Amino Acid MW of AA Side Chain Deriv Deriv MW Tmp
°C
TLC
Rf (A) Rf (B)
Alanine 71.08 · 18.02 - 311.34 152-153 0.57 0.45
Arginine 156.19 · 18.02 - 396.5 163-170 - -
Arginine 156.19 · 18.02 Pbf 348.78 - - -
Asparagine 114.10 · 18.02 - 354.4 184-187 - 0.25
Asparagine 114.10 · 18.02 Trt 596.69 211-213 - -
Aspartic Acid 115.09 · 18.02 OtBu 411.46 147-149 0.54 0.30
Cysteine 102.14 · 18.02 Trt 585.73 116 (dec) - 0.50
Glutamic Acid 129.12 · 18.02 OtBu 425.49 90-93 0.73 0.45
Glutamine 128.13 · 18.02 - 368.4 220 (dec) 0.10 -
Glutamine 128.13 · 18.02 Trt 610.73 120-135 - -
Glycine 57.05 · 18.02 - 297.31 174-177 0.46 -
Histidine 137.14 · 18.02 Trt 619.73 145 (dec) - 0.70
Hydroxyproline 112.11 · 18.02 tBu 409.49 151-154 - 0.50
Isoleucine 113.16 · 18.02 - 353.42 143-145 0.77 0.45
Leucine 113.16 · 18.02 - 353.42 152-154 0.76 0.40
Lysine 128.18 · 18.02 Boc 468.55 125-129 0.72 -
Methionine 131.20 · 18.02 - 371.46 129-132 0.68 0.50
Norleucine 113.16 · 18.02 - 353.42 138-140 - 0.45
Ornithine 114.15 · 18.02 Boc 454.52 113-116 - 0.53
Phenylalanine 147.18 · 18.02 - 387.44 181-183 0.65 0.40
Proline 97.12 · 18.02 - 337.38 107-110 0.80 0.35
Sarcosine 71.08 · 18.02 - 311.34 - - -
Serine 87.08 · 18.02 tBu 383.45 128-130 0.80 0.40
Threonine 101.11 · 18.02 tBu 397.48 129-131 0.90 0.50
Tryptophan 186.22 · 18.02 - 426.48 175-180 0.55 0.30
Tryptophan 186.22 · 18.02 Boc 526.59 - - -
Tyrosine 163.18 · 18.02 tBu 459.55 145-150 0.68 -
Valine 99.13 · 18.02 - 339.39 143-144 0.77 0.55

TLC refers to (A) Chloroform:Acetic Acid : 95:5 v/v
(B) Chloroform:Methanol:Acetic Acid : 90:8:2 v/v/v

TLC Information partially taken from Solid-Phase Peptide Synthesis,
Eds. J. M. Stewart and J. Young, Pierce Chemical Company, 1984 (solvent system A)
and partially taken from G. B.Fields and R. L. Nobel, Int. J. Peptide Protein Res. 35, 161 (1990).

Residues color coded by side chain properties

Non-Polar Polar Basic Acidic
Return to the Reference Menu

Return to the PI Home Page

PEPTIDES INTERNATIONAL
Phone: 502-266-8787 or 800-777-4779 (USA)
Fax: 502-267-1FAX (1329)
peptides@pepnet.com
11621 Electron Drive
Louisville, Kentucky 40299 USA