| New mini-PEGTM
Amino Acid Derivatives for Peptide Synthesis Boc-mini-PEGTM and Fmoc-mini-PEGTM Now Introducing Fmoc-mini-PEG-3TM Available from Peptides International |
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Are you looking for a new linker? A solubilizing bioconjugate? Or a new hydrophilic amino acid? |
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mini-PEGTM (8-Amino-3,6-Dioxaoctanoic Acid, AEEA) is a hydrophilic bifunctional spacer used for peptide and peptide nucleic acid (PNA) synthesis.1,2 The popular solubilizing linker, mini-PEG™ is now available in a slightly longer version. These hydrophilic amino acids are widely used in both peptide and peptide nucleic acid (PNA) syntheses. Linkers, such as mini-PEG, can be used to minimize the adverse effects of bulky labeling reagents on hybridization properties of PNA oligomers or to enhance binding to lipid surfaces. Fmoc-mini-PEGTM (FXX-5521-PI) was recently used in tandem (X-AEEA-AEEA-Y) as a linker for a peptide oligonucleotide conjugate employed for the construction of peptide chips.3 In another application, Fmoc-mini-PEG was coupled to a glycopeptide antibiotic, vancomycin, for covalent attachment to titanium metal, which is reported to yield an implant device with reduced infections.4
In addition to
Fmoc-mini-PEG, both Boc- and Fmoc-protected derivatives of
11-amino-3,6,9-trioxaundecanoic acid are n
1. A.M.P. Koskinen, T.
Valo, S. Vihavainen, and J.M.L. Hakala,
Bioorg.
Med. Chem. Lett.,5,
573 (1995). |
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mini-PEGTM Product Brochure PDF |
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