Muscarinic Toxins (MT1, MT3, MT7) MTalpha, synthetic toxin, MTa, Available from Peptides International

Muscarinic Toxins
MT1, MT3, MT7, and MTa
Manufactured by the Peptide Institute and Now Available from Peptides International

There are 5 subtypes (M1-M5) of muscarinic acetylcholine receptor belonging to the G protein-coupled receptor family that are expressed in mammalian brain. Elucidation of receptor subtype requires specific ligands. Peptides from snake venom (64-66 residues) have been found to bind with subtype specificity and therefore are named "muscarinic toxins." We now introduce Muscarinic Toxin 3, a selective M4 antagonist, in addition to MT1 and MT7. Muscarinic Toxin 7 (MTx7, MT7) is reported to be an M1 specific ligand . While Muscarinic Toxin 1 (MTx1, MT1) is reported to bind to both M1 and M3 with slightly higher affinity for M1, MT1 acts as an agonist in improving memory consolidation when injected into the dorsal hippocampus. MT1 has also been implicated as a tool for further investigation of Alzheimer’s research.

Manufactured by the Peptide Institute and Available from Peptides International Muscarinic Toxins 1) K.N Bradley, Pharmacol. Ther., 85, 87 (2000). (Review) 2) L.T. Potter, Life Sci., 68, 2541 (2001). (Review)
CODE	PRODUCT	QTY	USD
PMT-4341-s	Muscarinic Toxin 1 (Green Mamba, Dendroaspis angusticeps) [MTx1, MT1] Leu-Thr-Cys-Val-Thr-Ser-Lys-Ser-Ile-Phe-Gly-Ile- Thr-Thr-Glu-Asn-Cys-Pro-Asp-Gly-Gln-Asn-Leu- Cys-Phe-Lys-Lys-Trp-Tyr-Tyr-Ile-Val-Pro-Arg- Tyr-Ser-Asp-Ile-Thr-Trp-Gly-Cys-Ala-Ala-Thr-Cys- Pro-Lys-Pro-Thr-Asn-Val-Arg-Glu-Thr-Ile-Arg- Cys-Cys-Glu-Thr-Asp-Lys-Cys-Asn-Glu (Disulfide bond between Cys³-Cys²⁴, Cys¹⁷-Cys⁴², Cys⁴⁶-Cys⁵⁸, and Cys⁵⁹-Cys⁶⁴) (M.W. 7509.6) C₃₂₆H₄₉₉N₈₇O₁₀₁S₈ Agonist for Muscarinic Acetylcholine Receptor-1 (M1) 1) M. Jolkkonen, A. Adem, U. Hellman, C. Wernstedt, and E. Karl, Toxicon, 33, 399 (1995). (Original-Structure) 2) D. Jerusalinsky and A.L. Harvey, Trends in Pharmacol. Sci., 15, 424 (1994). (Review; Toxin for Muscarinic Receptors) 3) A. Adem and E. Karlson, Life Sci., 60, 1069 (1997). (Pharmacology) 4) H. Nishio, Y. Nishiuchi, T. Inui, K.N Bradley, A.L. Harvey, and T. Kimura, Peptide Science 1999, 125 (2000). (S-S Bond)	0.1 mg vial	315
PMT-4340-s	Muscarinic Toxin 7 (Green Mamba, Dendroaspis angusticeps) [MTx7, MT7] Leu-Thr-Cys-Val-Lys-Ser-Asn-Ser-Ile-Trp-Phe-Pro- Thr-Ser-Glu-Asp-Cys-Pro-Asp-Gly-Gln-Asn-Leu- Cys-Phe-Lys-Arg-Trp-Gln-Tyr-Ile-Ser-Pro-Arg-Met- Tyr-Asp-Phe-Thr-Arg-Gly-Cys-Ala-Ala-Thr-Cys- Pro-Lys-Ala-Glu-Tyr-Arg-Asp-Val-Ile-Asn-Cys-Cys- Gly-Thr-Asp-Lys-Cys-Asn-Lys (Disulfide bond between Cys³-Cys²⁴, Cys¹⁷-Cys⁴², Cys⁴⁶-Cys⁵⁷, and Cys⁵⁸-Cys⁶³) (M.W. 7472.5) C₃₂₂H₄₈₄ N₉₈O₉₆S₉ Specific Ligand for Muscarinic Acetylcholine Receptor-1 (M1) 1) A. Adem and E. Karlson, Life Sci., 60, 1069 (1997). (Original) 2) H. Nishio, Y. Nishiuchi, T. Inui, K.N Bradley, A.L. Harvey, and T. Kimura, Peptide Science 1999, 125 (2000). (S-S Bond) 3) J.M. Carsi and L.T. Potter, Toxicon, 38, 187 (2000). (Original; m1-toxin1) 4) Z. Gu, P.Zhong, and Z. Yan, J. Biol. Chem.,, 278, 17546 (2003).( Pharmacology; Inhibition of b-Amyloid Signalling)	0.1 mg vial	315
PMT-4410-s	Muscarinic Toxin 3 (Green Mamba, Dendroaspis angusticeps) [MT3, MTX3, m4-toxin] Synthetic Product Leu-Thr-Cys-Val-Thr-Lys-Asn-Thr-Ile-Phe-Gly-Ile-Thr-Thr-Glu-Asn-Cys-Pro-Ala-Gly-Gln-Asn-Leu-Cys-Phe-Lys-Arg-Trp-His-Tyr- Val-Ile-Pro-Arg-Tyr-Thr-Glu-Ile-Thr-Arg-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ile-Pro-Glu-Asn-Tyr-Asp-Ser-Ile-His-Cys-Cys-Lys-Thr-Asp-Lys-Cys-Asn-Glu (Disulfide bonds between Cys³- Cys²⁴, Cys¹⁷- Cys⁴², Cys⁴⁶- Cys⁵⁷, and Cys⁵⁸- Cys⁶³) (M.W. 7379.40 ) C₃₁₉H₄₈₉N₈₉O₉₇S₈ Specifc Ligand for Muscarinic Acetylcholine Receptor-4 (M4) 1) M. Jolkkonen, P.L.M. van Giersbergen, U. Hellman, C. Wernstedt, and E. Karlsson, FEBS Lett., 352, 91 (1994). (Original; MT3) 2) J.-S. Liang, J. Carsi-Gabrenas, J.L. Krajewski, J.M. McCafferty, S.L. Purkerson, M.P. Santiago, W.L. Strauss, H.H. Valentine, and L.T. Potter, Toxicon, 34, 1257 (1996). (Original; m4-toxin) 3) A. Adem and E. Karlsson, Life Sci., 60, 1069 (1997). (Pharmacol.; Muscarinic Receptor Subtype Specificity) 4) S. Katayama, M. Ishimaru, H. Nishio, Y. Nishiuchi, and T. Kimura, Peptide Science 2004, 161 (2005). (S-S Bond)	0.1 mg vial	315
PMT-4424-s NEW!	Muscarinic Toxin a (Green Mamba, Dendroaspis angusticeps) [MTalpha, MTa, MTa] Leu-Thr-Cys-Val-Thr-Ser-Lys-Ser-Ile-Phe- Gly-Ile-Thr-Thr-Glu-Asn-Cys-Pro-Asp-Gly- Gln-Asn-Leu-Cys-Phe-Lys-Lys-Trp-Tyr-Tyr- Leu-Asn-His-Arg-Tyr-Ser-Asp-Ile-Thr-Trp- Gly-Cys-Ala-Ala-Thr-Cys-Pro-Lys-Pro-Thr- Asn-Val-Arg-Glu-Thr-Ile-His-Cys-Cys-Glu- Thr-Asp-Lys-Cys-Asn-Glu (Disulfide bond between Cys³-Cys²⁴, Cys¹⁷-Cys⁴², Cys⁴⁶-Cys⁵⁸, and Cys⁵⁹-Cys⁶⁴) (M.W. 7545.4) C₃₂₆H₄₉₁N₈₉O₁₀₂S₈ Ligand for Muscarinic Acetylcholine Receptor-3/5 (M3/M5) (Non-specific Ligand) 1) M. Jolkkonen, P.L.M. van Giersbergen, U. Hellman, C. Wernstedt, A. Oras, N. Satyapan, A. Adem, and E. Karlsson, Eur. J. Biochem., 234, 579 (1995). (Original; MTa) 2) A. Adem and E. Karlsson, Life Sci., 60, 1069 (1997). (Pharmacol.; Muscarinic Receptor Subtype Specificity) 3) M. Jolkkonen, A. Oras, T. Toomela, E. Karlsson, J. Järv, and K.E.O. Åkerman, Toxicon, 39, 377 (2001). (Pharmacol.; Mechanism of Receptor Binding)	0.1 mg vial	315

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