Psalmotoxin 1: ASIC1a Selective Blocker, Synthetic Tarantula Peptide Toxin Now Available from Peptides International

Psalmotoxin 1: ASIC1a Selective Blocker
Synthetic Tarantula PeptideToxin

The acid-sensing ion channel (ASIC) family is involved with pain perception, learning, and memory. In addition, the ion channels may contribute to brain injury and neuronal death. ASICs are stimulated by H+ ligand and their activation is calcium dependent [1,2].

Peptide toxins have been invaluable tools for inhibition of ion conductance pathways and in functional/structural studies of channels. Psalmotoxin 1 (PTX-4435-s), isolated from the venom of tarantula Psalmopoeus cambridgei, is the first potent peptide blocker shown to inhibit ASIC1a by increasing affinity of the channel for H+, leading to receptor desensitization [4,5,6]. This toxin showed promise as a neuroprotective agent for ASIC1a mediated ischemic brain injury (100 ng/ml) and could selectively inhibit malignant glioma (IC₅₀ = 36 pM) Na+ channels (both inward and outward) [7,8]. Further studies of Psalmotoxin ASIC1a interaction could lead to potential diagnosis and therapy of these and other ASIC1a-related diseases.

Product Brochure: Psalmotoxin 1
CODE	PRODUCT	QTY	USD
PTX-4435-s NEW!	Psalmotoxin 1 PcTX1 (South American Tarantula, Psalmopoeus cambridgei) (Trifluoroacetate Form) Synthetic Product Glu-Asp-Cys-Ile-Pro-Lys-Trp-Lys-Gly-Cys-Val-Asn-Arg-His-Gly-Asp-Cys-Cys-Glu-Gly-Leu- Glu-Cys-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys-Val-Pro-Lys-Thr-Pro-Lys-Thr (Disulfide bonds between Cys³-Cys¹⁸, Cys¹⁰-Cys²³, and Cys¹⁷- Cys³³) (M.W. 4689.4) C₂₀₀H₃₁₂N₆₂O₅₇S₆ Selective Blocker for Acid-Sensitive Ion Channel, ASIC1a	0.1 mg vial	245

1. E.L. Bässler, T.J. Ngo-Anh, H.S. Geisler, J.P. Ruppersberg, and S.Gründer, J. Biol. Chem., 276, 33782 (2001).
2. E. Babini, M. Paukert, H.S. Geisler, and S. Gründer, J.Biol. Chem., 277, 41597 (2002).
3. V.I. Pidoplichko and J.A. Dani, PNAS, 203, 11376 (2006).
4. P. Escoubas, J.R. De Weille, A. Lecoq, S. Diochot, R. Waldmann, G. Champigny, D. Moinier, A. Menez, and M. Lazdunski, J. Biol. Chem., 275, 25116 (2000).
5. M. Salinas, L.D. Rash, A. Baron, G. Lambeau, P. Escoubas, and M. Lazdunski, J. Physiol., 570, 339 (2005).
6. X. Chen, H. Kalbacher, and S. Gründer, J. Gen. Physiol., 126, 71 (2005).
7. G. Pignataro, R.P. Simon, and Z.-G. Xiong, Brain, 10, 1093 (2006).
8. J.K. Bubien, H.-L. Ji, G.Y. Gilespie, C.M. Fuller, J.M. Markert, T.B. Mapstone, and D.J. Benos, Am. J. Physiol. Cell Physiol., 287, C1282 (2004).

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